Spiritleaf – Medicine Hat is now open! The City of Medicine Hat is a thriving community located along the South Saskatchewan River, east of Lethbridge and southeast of Calgary. Surrounded by coulees and rolling prairies, Medicine Hat is a vibrant city. This growing regional service centre supports many industries, such as manufacturing, petrochemicals, oil & gas services, agricultural processing and services, retail and public sector services; often referred to as the Medicine Hat Advantage!